Kaletra – Everything You Need to Know

When working with Kaletra, a fixed‑dose combination of lopinavir and ritonavir used to treat HIV infection. Also known as Kaletra (lopinavir/ritonavir), it forms a core part of modern antiretroviral therapy.

HIV (Human Immunodeficiency Virus) is the virus that attacks the immune system, and managing it requires a lifelong regimen called antiretroviral therapy, a combination of medicines that suppress viral replication and keep CD4 counts stable. Within this regimen, protease inhibitors, a drug class that blocks the HIV protease enzyme, preventing the virus from maturing play a critical role. Kaletra belongs to this class, meaning it directly stops the virus from creating new infectious particles.

Because Kaletra mixes two protease inhibitors, it brings specific advantages and challenges. The ritonavir component boosts lopinavir levels, allowing once‑twice‑daily dosing, which many patients find easier than multi‑pill schedules. However, this boost also means Kaletra interacts with a wide range of other drugs—especially those metabolized by the liver enzyme CYP3A4. Common culprits include certain cholesterol‑lowering meds, some antibiotics, and even over‑the‑counter herbal supplements. Monitoring liver enzymes and lipid profiles becomes essential, especially for patients who also take statins or antifungals. Side effects range from mild gastrointestinal upset to more serious concerns like elevated triglycerides or insulin resistance. Understanding these trade‑offs helps clinicians tailor therapy to each person’s health profile.

Our collection below dives deeper into practical aspects of Kaletra use. You’ll find comparisons with other antiretrovirals, dosage adjustment tips for special populations, and clear guidance on handling drug‑drug interactions. Whether you’re starting treatment, managing side effects, or looking to switch to a newer regimen, the articles ahead give actionable insights you can apply right away. Kaletra is more than a pill—it’s a piece of a larger treatment puzzle, and the resources below will help you see how it fits into your overall health plan.