Ledipasvir — what it is and how it helps treat hepatitis C

Ledipasvir is an antiviral drug you’ll usually see combined with sofosbuvir (the combo is commonly called Harvoni). It targets the NS5A protein of the hepatitis C virus (HCV), stopping the virus from copying itself. That makes it a core option for curing many people with genotype 1 HCV and some other genotypes when used as part of a full treatment plan.

Practical facts: dosing, monitoring, and how it’s taken

The standard tablet combines ledipasvir 90 mg with sofosbuvir 400 mg and is taken once daily, often for 8 to 12 weeks depending on your medical situation. Your doctor decides the exact length based on things like prior treatment history, viral genotype, and whether you have cirrhosis. You’ll usually have blood tests during treatment — viral load checks at about 4 weeks, at the end of therapy, and around 12 weeks after finishing to confirm cure (called sustained virologic response or SVR).

Some quick, useful tips:

• Take the pill at the same time each day, with or without food.
• Don’t stop early — finishing the full course is key to cure and to avoid resistance.
• Your provider may add other medicines (like ribavirin) in special cases.

Side effects and important drug interactions

Most people tolerate ledipasvir/sofosbuvir well. The common side effects are fatigue, headache, and nausea. Serious problems are uncommon but can happen — report new dizziness, fainting, severe rash, or breathing trouble right away.

Watch for these interactions and issues:

• Acid-reducing drugs (antacids, H2 blockers, PPIs) can cut ledipasvir absorption. If you use antacids, separate them by several hours and ask your provider about timing for PPIs.
• Amiodarone combined with sofosbuvir has been linked to serious slow heart rates. Don’t combine them unless closely monitored.
• Tell your provider about all medicines and supplements. Even common over-the-counter pills can matter.

If you have severe kidney disease or complex liver disease, dosing and safety need careful review. Sofosbuvir is processed by the kidneys, so kidney function affects decisions. Pregnant people or those breastfeeding should discuss risks and timing with their clinician.

Want to know more? Ask your doctor or pharmacist for a clear plan: how long you’ll take treatment, which tests you’ll need, and what to do about other medicines. Ledipasvir isn’t sold over the counter — it requires a prescription and medical follow-up to make sure the infection is cured safely.